Serotonin antagonists, their preparation and medications containing them
US5130313A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1990 |
| Grant date | Jul 14, 1992 |
| Priority date | — |
| Expiry date | Dec 13, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds of formula: ##STR1## in which R.sub.1 denotes PA2 a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by an optionally substituted phenyl, optionally substituted 3-indolyl or 3-(5-hydroxyindolyl) radical, PA2 a 1-piperazinyl radical substituted in the 4-position by an optionally substituted phenyl, 1,2-benzisothiazol-3-yl, 1,2-benzisoxazol-3-yl or 2-pyridyl radical, PA2 a piperidino radical substituted in the 4-position by an optionally substituted phenyl, bis(4-fluorophenyl)methylene, 4-fluorobenzoyl, optionally substituted 2-oxo-1-benzimidazolinyl, optionally substituted 3-indolyl or 3-(5-hydroxyindolyl) radical, by two phenyl radicals or a hydroxyl radical and an optionally substituted phenyl radical PA1 R.sub.2 denotes a radical SO.sub.2 R.sub.4 in which R.sub.4 denotes an alkyl or phenyl radical, PA1 R.sub.3 denotes a phenyl or naphthyl radical, PA1 or else R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached form a ring, PA1 n is equal to 2, 3 or 4, processes for their preparation and medications containing them. The invention relates to treating a disease ameliorated by serotonin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.