Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compounds

US5130317A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Ekkehard Baader · Königstein, DE
• Martin Bickel · Frankfurt am Main, DE
• Volkmar Gunzler-Pukall · Marburg, DE
• Stephan Henke · Bad Soden am Taunus, DE

Key dates

• Filing date: Sep 19, 1990
• Grant date: Jul 14, 1992
• Expiry date: Sep 19, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compounds The invention relates to pyrimidine-4,6-dicarboxylic acid diamides of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can be employed as fibrosuppressants and immunosuppressants.