Hypoglycemic thiazolidinedione derivatives
US5130379A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1991 |
| Grant date | Jul 14, 1992 |
| Priority date | — |
| Expiry date | Mar 26, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Hypoglycemic thiazolidine-2,4-dione derivatives ##STR1## wherein the dotted line represents a bond or no bond; PA1 V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N-- or S; PA1 W is CH.sub.2, CHOH, CO, C.dbd.NOR or --CH.dbd.CH--; PA1 X is S, O, NR.sup.1, --CH.dbd.N-- or --N.dbd.CH--; PA1 Y is CH or N; PA1 Z is hydrogen, (C.sub.1 -C.sub.7)alkyl, (C.sub.3 -C.sub.7) cycloalkyl, phenyl, naphthyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C.sub.1 -C.sub.3)alkyl, trifluoromethyl, (C.sub.1 -C.sub.3)alkoxy, fluoro, chloro or bromo; PA1 Z.sup.1 is hydrogen or (C.sub.1 -C.sub.3)alkyl; PA1 R is hydrogen or methyl; and PA1 n is 1, 2 or 3; a pharmaceutically acceptble cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.