Synthetic peptide endowed with immunological activity, capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein, and their use in the diagnostic field

US5130415A · kind A · utility

Assignee

• Sclavo SpA · IT

Inventors

• Mario F. Tecce · Siena, IT
• Marzia Monica Giuliani · Siena, IT
• Stefano Ricci · Siena, IT
• Giulio Ratti · Siena, IT
• Benedetto Terrana · Siena, IT

Key dates

• Filing date: Jul 24, 1989
• Grant date: Jul 14, 1992
• Expiry date: Jul 24, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38-119 region of human alpha-fetoprotein. Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported. The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.