Production of 2',3'-dideoxy-2',3'-didehydronucleosides

US5130421A · kind A · utility

Assignee

• Bristol-Meyers Company · US

Inventors

• John E. Starrett, Jr. · Middletown, US
• Muzammil M. Mansuri · Lexington, US
• John C. Martin · Los Alamos, US
• Carl E. Fuller · Warners, US
• Henry G. Howell · East Syracuse, US

Key dates

• Filing date: Apr 29, 1991
• Grant date: Jul 14, 1992
• Expiry date: Apr 29, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficiency viruses (HIV).