2-substituted imidazoquinoxaline diones, a new class of GABA brain receptor ligands
US5130430A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 31, 1990 |
| Grant date | Jul 14, 1992 |
| Priority date | — |
| Expiry date | Oct 31, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent organic or inorganic substituents; X represents hydrogen, halogen, hydroxy or amino and W represents phenyl, thienyl or pyridyl, each of which may be unsubstituted or mono or disubstituted with organic or inorganic substituents. These compounds are highly selective agonists, antagonists or inverse agonists for GABA a brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.