Tablets of the hydrophilic matrix type based on salbutamol and a process for their preparation
US5132116A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 18, 1991 |
| Grant date | Jul 21, 1992 |
| Priority date | — |
| Expiry date | Oct 18, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to tablets of the type which contain a homogeneous dispersion of an active principle based on salbutamol or on one of its derivatives in a hydrophilic matrix, ensuring: PA1 in vitro, long-term release of the active principle, which is constant and independent of pH, over a time interval of about 12 hours, PA1 in vivo, uptake kinetics of the active principle by the organism of zero order over a time interval of 6 hours, the said matrix containing at least one swelling agent and a diluent in a weight ratio of swelling agent/diluent lying between 0.2 and 0.6, and being preferably equal to about 0.4. The present invention also covers the process for the preparation of these tablets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.