Microbial transformation process for antihypertensive products
US5132216A · kind A · utility
1Cited by
2References
3Claims
0Family size
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Key dates
| Filing date | Jun 7, 1991 |
| Grant date | Jul 21, 1992 |
| Priority date | — |
| Expiry date | Jun 7, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/806
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fermentation of the microorganism Streptomyces sp. MA6744 (ATCC No. 55041) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields a 7-hydroxymethyl, a 5,7-dihydroxymethyl, a 7-carboxy and a 1'-hydroxy-5-hydroxymethyl analog, all of which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.