11.beta.-phenyl-4,9,15-estratrienes, their manufacture and pharmaceutical preparations containing same

US5132299A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Eckhard Ottow · Berlin, DE
• Helmut Hofmeister · Berlin, DE
• Stefan Scholz · Berlin, DE
• Guenter Neef · Berlin, DE
• Walter Elger · Berlin, DE
• Sybille Beier · Berlin, DE
• Krzysztof Chwalisz · Berlin, DE

Key dates

• Filing date: Jan 16, 1990
• Grant date: Jul 21, 1992
• Expiry date: Jan 16, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0083
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New 11.beta. phenyl-4,9,15-estratrienes of formula I ##STR1## are described, where X implies an oxygen atom or a hydroxyimino grouping N.about.OH, PA1 R.sup.1 stands for a hydrogen atom or a methyl group, PA1 R.sup.2 implies a hydrogen atom, an alkyl radical or an acyl radical with in each case 1 to 10 carbon atoms, PA1 R.sup.3 stands for a hydrogen atom, a cyanomethyl group, --(CH.sub.2).sub.n CH.sub.2 Z where n implies the numbers 0, 1, 2, 3, 4 or 5, Z=--H or --OR.sup.5 with R.sup.5 having the significance of a hydrogen atom or an alkyl or acyl group with in each case 1 to 10 carbon atoms, or for --(CH.sub.2).sub.m --C.tbd.C--Y where m=0-2 and Y implies a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl group with in each case 1 to 10 carbon atoms, PA1 R.sup.4 represents a straight-chain or branched-chain, saturated or unsaturated hydrocarbon radical with up to 8 carbon atoms which contains the grouping ##STR2## with X having the above significance. The compounds have antigestagenic and antiglucocorticoid activity.