Etoposide analogues

US5132322A · kind A · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Kuo-Hsiung Lee · Chapel Hill, US
• Zhe Wang · Wilmington, US
• J. Phillip Bowen · Hull, US
• Dora M. Schnur · Hillsborough Township, US
• Yung-Chi Cheng · Woodbridge, US
• Su-Ying Liu · Belmont, US
• Yao-Haur Kuo · Gaodong, CN
• Masami Mori · Ebeye, US

Key dates

• Filing date: Sep 12, 1989
• Grant date: Jul 21, 1992
• Expiry date: Sep 12, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: ##STR1## where: R.sub.1 is .beta.-OCH.sub.2 CH.sub.2 NH.sub.2 .beta.-NHCH(CH.sub.3)CH.sub.2 OH, .beta.-NHCH.sub.2 CH(CH.sub.3)OH, .beta.-Cl, .beta.-Br, .beta.-OH, .alpha.-OH, .beta.-NH, .alpha.-NH.sub.2, .beta.-NHCH.sub.2 CH.sub.2 OH, .alpha.-NHCH.sub.2 CH.sub.2 OH, .beta.-NHCH.sub.2 CH.sub.2 CH.sub.3, .beta.-NHCH.sub.2 CH.sub.2 OCH.sub.3, .beta.-NHCH.sub.2 CH.dbd.CH.sub.2, .beta.-NHCH.sub.2 CH(OH)CH.sub.3, .beta.-NHCH.sub.2 CH.sub.2 CH.sub.2 OH, .beta.-OCH.sub.2 CH.sub.2 OH, ##STR2## R.sub.2 is H, or Br; R.sub.1 is H, or Br; PA0 R.sub.4 is H, or Br; PA0 R.sub.5 is H, or Br; and PA0 R.sub.6 is H, or --CH.sub.3.