Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles
US5133908A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1989 |
| Grant date | Jul 28, 1992 |
| Priority date | — |
| Expiry date | Jun 30, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/84
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The Process according to the invention comprises: PA0 (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, PA0 (2) the preparation of a second liquid phase consisting essentially of a non-solvent of a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, PA0 (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance and, PA0 (4) if desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to produce a powder of nanoparticles. Said substance may be a protein. Field of use: chemistry, biochemistry, pharmacy, medicine, cosmetics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.