Vaccines comprising yeast-derived hepatits B virus polypeptides
US5133961A · kind A · utility
15Cited by
9References
1Claims
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Key dates
| Filing date | Jun 29, 1987 |
| Grant date | Jul 28, 1992 |
| Priority date | — |
| Expiry date | Jun 29, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/223
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The entire hepatitis B virus pre-S antigen gene linked in one contiguous reading frame to the hepatitus B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.