14.alpha.,17.alpha.-ethanoestratrienes

US5134136A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerald Kirsch · Berlin, DE
• Henry Laurent
• Rudolf Wiechert · Berlin, DE
• Sybille Beier · Berlin, DE
• Walter Elger · Berlin, DE
• James R. Bull · Pretoria, ZA
• Gunter Neef · Berlin, DE

Key dates

• Filing date: May 13, 1991
• Grant date: Jul 28, 1992
• Expiry date: May 13, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/002
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

##STR1## New 14.alpha.,17.alpha.-ethano-estratrienes of general formula (I) wherein R.sup.1 is a hydrogen atom, an alkyl or acyl group with 1 to 12 carbon atoms, R.sup.2 is a hydrogen atom or a methyl group, R.sup.3 is a hydrogen atom or an acyl group with 1 to 12 carbon atoms and (a) is either (II) or (III), where R.sup.4 is an alkyl residue in the .alpha. or .beta. position with 1 to 8 carbon atoms or an .alpha.,.beta.-alkenyl residue which may contain several double bonds or an .alpha.,.beta.-alkinyl residue, both with 2 to 8 carbon atoms, are described. Also described is a process for producing them. These new compounds have a marked oestrogenic activity.