Process for activating a polymer surface for covalent bonding for subsequent coating with heparin or the like
US5134192A · kind A · utility
76Cited by
9References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1991 |
| Grant date | Jul 28, 1992 |
| Priority date | — |
| Expiry date | Feb 14, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31551
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A dicarbonyl halide preferably a straight-chain-alkyl dicarbonyl dihalide, may be used to activate a substrate surface of preferably polyurethane or polyamide. Optionally, an amine-end blocked polymer may be reacted with the resulting activated surface by reaction between amine and dicarbonyl halide groups. Then, a material to be covalently bonded to said surface, such as heparin, may be reacted with free amine groups bonded to the surface by a carbodiimide process or the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.