Process for the preparation of amino acid-derived enatiomeric compounds
US5136076A · kind A · utility
12Cited by
1References
4Claims
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Key dates
| Filing date | Jun 19, 1990 |
| Grant date | Aug 4, 1992 |
| Priority date | — |
| Expiry date | Jun 19, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The (R) or (S) isomer of acetorphan or N-12-acetylthiomethyl-1-oxo-3-phenyl propyl/(S) alanine methyl ester is prepared by splitting of racemic 3-acetylthio-2-benzyl propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.