Biphenyl-5,5'-bis-alkanoic acid derivatives, their production and aldose reductase inhibitors containing the same
US5136090A · kind A · utility
3Cited by
1References
2Claims
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Key dates
| Filing date | Aug 8, 1991 |
| Grant date | Aug 4, 1992 |
| Priority date | — |
| Expiry date | Aug 8, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An aldose reductase inhibitor, comprising a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof as the effective component, in which R denotes an alkyl of C.sub.1-12, ##STR2## wherein X.sub.1 and X.sub.2 are same or different and are hydrogen or halogen, cyclohexylmethyl, cyclohexyl, tetra-hydro-2H-pyran-1-yl-methyl, carboxy-lower alkyl or cyclo-lower alkyl and n is 2 or 3. These compounds exhibit a superior aldose reductase inhibiting activity with simultaneous high stability, and are for use in the prevention and therapy of diabetic complications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.