Deactivated supports for liquid chromatographic separation of silanophiles
US5137627A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 10, 1990 |
| Grant date | Aug 11, 1992 |
| Priority date | — |
| Expiry date | May 10, 2010 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2220/58
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Silica gel chromatographic supports surface-modified with (R.sup.1 O).sub.3-m Si R.sup.2.sub.m(CH.sub.2).sub.3 NH(CH.sub.2 CH.sub.2 NH).sub.n H, in which R.sup.1 is a C.sub.1 -C.sub.5 alkyl, R.sup.2 is methyl or ethyl, and m and n are independently selected from the integers 0, 1 or 2, and further modified chemically to produce reverse-phase character, markedly reduce the interaction between silanophilic analytes and the silanol groups present on the surface of the silica gel through the presence of polar groups, which include the residual unmodified amino and modified amino groups, and which are densely packed near the silica surface. This results in chromatographic elution of basic, silanophilic analytes in efficient, narrow bands similar to those of the less-polar analytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.