Treatment to reduce edema for brain and musculature injuries
US5137871A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 28, 1989 |
| Grant date | Aug 11, 1992 |
| Priority date | — |
| Expiry date | Jul 28, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Administration of a Corticotropin-Releasing Factor (or a salt of analog thereof) decreases the leakage of blood components into brain tissue produced by various adverse medical conditions and reduces bleeding when muscle tissues are cut and handled, such as in plastic and reconstructive surgery. A method of treating a patient for injury to or disease of the brain, central nervous system, or musculature in which edema is a factor comprises administering to the patient a Corticotropin-Releasing Factor (or salt or analog) in an amount effective to decrease vascular permeability in the injured or diseased brain, nervous system tissue or musculature, and thereby to reduce edema. Administration in accordance with the method can be about two hours before surgery, or can be up to three days after injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.