Substituted aminomethyltetralins and their heterocyclic analogues

US5137901A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Bodo Junge · Wuppertal, DE
• Rudolf Schohe · Wuppertal, DE
• Peter-Rudolf Seidel · Cologne, DE
• Thomas Glaser · Overath, DE
• Jorg Traber · Lohmar, DE
• Ulrich Benz · Goldkronach, DE
• Teunis Schuurman · Overath, DE
• Jean De Vry · Stolberg, DE

Key dates

• Filing date: Sep 26, 1989
• Grant date: Aug 11, 1992
• Expiry date: Sep 26, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.