Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
US5138036A · kind A · utility
38Cited by
4References
2Claims
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Key dates
| Filing date | Nov 13, 1989 |
| Grant date | Aug 11, 1992 |
| Priority date | — |
| Expiry date | Nov 13, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/27
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED.sub.50 0.0018 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 14 has the structural formula: ##STR1##
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