4-(2-Oxo-cyclohexyl) azetidinones

US5138048A · kind A · utility

Assignee

• Glaxo SpA · IT

Inventors

• Bruno Tamburini · Pescantina, IT
• Alcide Perboni · Verona, IT
• Tino Rossi · Verona, IT
• Daniele Donati · Nerviano, IT
• Daniele Andreotti · Verona, IT
• Giovanni Gaviraghi · Verona, IT
• Stefano Biondi · Verona, IT
• Claudio Bismara · Bovolone, IT

Key dates

• Filing date: Sep 7, 1990
• Grant date: Aug 11, 1992
• Expiry date: Sep 7, 2010

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; and PA0 R.sub.2 represents a hydrogen or halogen atom, an azido group, a C.sub.1-3 alkyl group, a group (CH.sub.2).sub.m OR.sub.3 wherein m is zero or one and R.sub.3 represents a hydrogen atom or a hydroxyl protecting group, an azidoethoxy group, a protected hydroxyethoxy group or a group XR.sub.4 in which X is an oxygen atom or the group S(O).sub.n in which n is zero, 1 or 2 and R.sub.4 represents a C.sub.1-5 alkyl, C.sub.3-7 cycloalkyl or phenyl group or when X is oxygen or sulphur then R.sub.4 may also represent the group AlkNR.sub.5 R.sub.6 in which Alk represents a C.sub.2-6 straight or branched alkylene chain and R.sub.5 and R.sub.6 independently represent a hydrogen atom or C.sub.1-4 alkyl group or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring or the group NR.sub.5 R.sub.6 represents a protected amino group, or R.sub.2 represents the group (CH.sub.2).sub.m NR.sub.7 R.sub.8 in which m is zero or 1 and R.sub.7 and R.sub.8 independently represent a hydrogen atom or a C.sub.1-4 alkyl group or NR.sub.7 R.su…