Patent · US Expired

Rapamycin analogs as immunosuppressants and antifungals

US5138051A · kind A · utility

147Cited by
6References
2Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 7, 1991
Grant dateAug 11, 1992
Priority date—
Expiry dateAug 7, 2011

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07H19/01
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Reduction of C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.