2-acyl-6-methylnaphthalene preparation
US5138098A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 1991 |
| Grant date | Aug 11, 1992 |
| Priority date | — |
| Expiry date | Mar 14, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/81
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A regioselective acylation process is provided for coverting a 2-methylnaphthalene compound to a 2-acetyl-6-methylnaphthalene compound. The process is conducted under liquid phase conditions in an acylation inert solvent using a complexing agent which is regiospecific for the beta position of naphthalene and which is a thermally stable nitrohydrocarbon compound. Preferred such agents are nitrobenzene, o-nitrotoluene, and mesitylene. Also provided is a novel method for producing a 2-acetyl-6-methylnaphthalene compound of relatively high purity from isomer mixtures by recrystallization from a hydrocarbon solvent, such as n-octane, isooctane, or n-nonane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.