Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine
US5139776A · kind A · utility
11Cited by
11References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1989 |
| Grant date | Aug 18, 1992 |
| Priority date | — |
| Expiry date | Feb 3, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/832
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a method for culturing Bordetella pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amount at low cost. From the antigen, there can be obtained a stable and effective pertussis toxoid to be used for a pertussis vaccine. There is also disclosed a vaccine comprising the pertussis toxoid as an active ingredient and a gelatin and/or gelatin derivatives as a stabilizing agent. The present vaccine is extremely stable and can be stored for a prolonged period of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.