Bispecific monoclonal antibody, its production and use
US5141736A · kind A · utility
33Cited by
5References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 27, 1989 |
| Grant date | Aug 25, 1992 |
| Priority date | — |
| Expiry date | Dec 27, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/972
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses, a bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, which can carry an anasamitocin derivative in a stable and inactive form at other sites than the target and release the active-form ansamitocin derivative at the target site, so that an anticancer agent having excellent durability and selectivity with little adverse action can be prepared using the bispecific monoclonal antibody and ansamitocin derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.