Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5141813A · kind A · utility
128Cited by
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2Claims
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Inventor
Key dates
| Filing date | Aug 28, 1989 |
| Grant date | Aug 25, 1992 |
| Priority date | — |
| Expiry date | Aug 28, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2982
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The subject invention concerns a novel multifunctional solid support reagent which is useful in solid phase oligonucleotide synthesis. Specifically, the reagent is used in a solid phase oligonucleotide process to chemically modify the 3' terminus of a synthetic oligonucleotide with any chemical functional group. The invention reagent can be used to construct 3' labeled oligonucleotide hybridization probes to detect the presence of a target polynucleotide in biological and clinical samples.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.