Purification procedure of TPA from crude preparations
US5141863A · kind A · utility
4Cited by
6References
4Claims
0Family size
Assignee
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Key dates
| Filing date | May 1, 1990 |
| Grant date | Aug 25, 1992 |
| Priority date | — |
| Expiry date | May 1, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/815
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tissue plasminogen activator (tPA) species having a specific molecular weight can be isolated in a purified form from a crude tPA preparation containing various tPA species having different molecular weights by bringing the crude tPA preparation into contact with hydroxyapatite and then separately eluting the adsorbed tPA species with eluents having different pHs and/or salt concentrations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.