1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase C
US5141957A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 5, 1990 |
| Grant date | Aug 25, 1992 |
| Priority date | — |
| Expiry date | Nov 5, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C225/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel substituted anthraquinones having the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently H, alkyl, aryl, or arylalkyl; PA1 m and n are independently 1, 2, or 3; PA1 X is H, OH, NR.sub.3 R.sub.4, Cl, Br, I, F, alkyl, aryl alkoxy, aroxy, COOR.sub.5, or CONR.sub.6 R.sub.7 ; PA1 R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently H, lower alkyl or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.