Fluorine-containing acetophenones optionally halogenated on the CH.sub.3 -group and their precurser fluorine-containing benzonitriles

US5142092A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ernst Kysela · Bensberg, DE
• Bernd Baasner · Bensberg, DE
• Klaus Schaller · Wuppertal, DE

Key dates

• Filing date: Jul 30, 1991
• Grant date: Aug 25, 1992
• Expiry date: Jul 30, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Fluorine-containing acetophenones, optionally halogenated on the CH.sub.3 group, of the formula ##STR1## in which X represents hydrogen, chlorine or bromine and the radicals R.sub.1 to R.sub.5 have the following meaning, PA2 a) R.sub.1 and R.sub.4 denote fluorine, R.sub.2 and R.sub.5 denote chlorine and R.sub.3 denotes CF.sub.3, or PA2 b) R.sub.1, R.sub.3 and R.sub.4 denote fluorine and R.sub.2 and R.sub.5 denote hydrogen, or PA2 c) R.sub.1, R.sub.4 and R.sub.5 denote hydrogen, R.sub.2 denotes chlorine and R.sub.3 denotes CF.sub.3, or PA2 d) R.sub.1, R.sub.4 and R.sub.5 denote hydrogen, R.sub.2 denotes chlorine and R.sub.3 denotes OCF.sub.3, or PA2 e) R.sub.1, R.sub.4 and R.sub.5 denote hydrogen and R.sub.2 and R.sub.3 denote CF.sub.3, or PA2 f) R.sub.1 denotes chlorine, R.sub.2 denotes CF.sub.3 and R.sub.3, R.sub.4 and R.sub.5 denote hydrogen, or PA2 g) R.sub.1 denotes chlorine, R.sub.2, R.sub.3 and R.sub.4 denote hydrogen and R.sub.5 denotes CF.sub.3, or PA2 h) R.sub.1 denotes chlorine, R.sub.2, R.sub.4 and R.sub.5 denote hydrogen and R.sub.3 denotes CF.sub.3 and a process for their preparation from the corresponding fluorinated benzonitriles or benzyl halides by reaction with an…