Cephalosporins, process for producing the same, intermediates thereof and process for producing the intermediates
US5144027A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 24, 1991 |
| Grant date | Sep 1, 1992 |
| Priority date | — |
| Expiry date | May 24, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond.about.represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.