Derivatives of 1-[3-(4-hydroxyphenyl) 1-hydroxy 1-propyl] benzene substituted in position 2 by an aminoalkyleneoxy chain, the method of preparing same and the application thereof to therapeutics
US5144029A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 3, 1991 |
| Grant date | Sep 1, 1992 |
| Priority date | — |
| Expiry date | Jan 3, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of formula: ##STR1## in which: R.sub.3 is hydrogen, 2-tetrahydropyranyl or benzyl; PA0 R.sub.1 and R.sub.2 are such that: PA1 either R.sub.1 represents a methoxy group in which case R.sub.2 is a group chosen from the following: hydroxyl; C.sub.1 -C.sub.4 alkyl; C.sub.2 -C.sub.8 alkyloxy; C.sub.5 -C.sub.7 cycloalkloxy; benzyloxy; PA1 or R.sub.2 represents a methoxy group in which case R.sub.1 is a group chosen from the following: hydroxyl; C.sub.2 -C.sub.8 alkyloxy; C.sub.2 -C.sub.8 alkyloxy substituted by a methoxy group; C.sub.1 -C.sub.4 trifluoroalkyloxy; C.sub.3 -C.sub.4 alkenyloxy; C.sub.5 -C.sub.7 cycloalkyloxy; benzyloxy; C.sub.1 -C.sub.4 alkylthio; PA0 n=2 or 3; and PA0 p=4, 5 or 6, as well as their addition salts with mineral or organic acids, said compounds and salts being useful as drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.