Process for producing optically active alcohol
US5144039A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1990 |
| Grant date | Sep 1, 1992 |
| Priority date | — |
| Expiry date | Jan 29, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The process for producing an optically active alcohol of the present invention comprises allowing PA0 (A) an optically active amino alcohol represented by the general formula (I) ##STR1## (R.sup.1 is an aryl group, R.sup.2 is a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and the carbon atoms having a mark * are each an asymmetric carbon atom) and an acid, or a salt of the optically active amino alcohol (I) and an acid, PA0 (B) a metal borohydride, and PA0 (C) at least one member selected from the group consisting of water, sulfides, cyclic ethers, ethers of mono alcohol to react with PA1 a prochiral ketone represented by the general formula (II) ##STR2## [R.sup.4 and R.sup.5 are different and each a lower alkyl group, an aryl group, an aralkyl group or a 2-substituted-1-triazoleethylene group represented by the general formula (III) ##STR3## (R.sup.6 is a halogen- or haloalkyl-substituted or unsubstituted phenyl group or a cycloalkyl group)]. According to the present invention, the optically active alcohol (IV) can be obtained with good efficiency and a high optical purity. Therefore, the present process is advantageous in industrial application, in partic…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.