14,17.alpha.-etheno- and -ethanoestratrienes, processes for the preparation of these compounds, as well as their use for the production of medicinal agents

US5145847A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Rolf Bohlmann · Berlin, DE
• Hermann Kunzer · Hermeskeil, DE
• Rudolf Wiechert · Berlin, DE
• David Henderson · Berlin, DE
• Martin Schneider · Remchingen, DE
• Yukishige Nishino · Berlin, DE

Key dates

• Filing date: Jul 27, 1990
• Grant date: Sep 8, 1992
• Expiry date: Jul 27, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel 14,17.alpha.-etheno- and -ethanoestratrienes according to general Formula I ##STR1## wherein X is a --CH.sub.2 --CH.sub.2 or ##STR2## R.sup.1 is a hydrogen atom, a C.sub.1 - to C.sub.15 -acyl, benzoyl, C.sub.1 - to C.sub.15 -alkyl, C.sub.3 - to C.sub.9 -cycloalkyl or alkylcycloalkyl group, and PA0 R.sup.2 is the grouping ##STR3## wherein R.sup.3 and R.sup.4 independently of each other mean a hydrogen atom or a straight-chain or branched, optionally partially or completely fluorinated C.sub.1 -C.sub.8 -alkyl group, a process for their preparation, pharmaceutical preparations containing these compounds, as well as their use for the production of medicinal agents. The novel compounds exhibit strong antiestrogenic efficacy.