HMG-COA reductase-inhibiting substituted amino-pyridines

US5145857A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Peter Fey · Wuppertal, DE
• Rolf Angerbauer · Wuppertal, DE
• Walter Hubsch · Wuppertal, DE
• Thomas Philipps · Cologne, DE
• Hilmar Bischoff · Wuppertal, DE
• Dieter Petzinna · Mülheim an der Ruhr, DE
• Delf Schmidt · Wuppertal, DE

Key dates

• Filing date: Aug 15, 1990
• Grant date: Sep 8, 1992
• Expiry date: Aug 15, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

HMG-COA reductase-inhibiting compounds of the formula ##STR1## in which X represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, PA0 R represents a group of the formula ##STR2## R.sup.1 represents optionally substituted aryl, R.sup.2 represents --CH.sub.2 OR.sup.8 or --X--R, and PA0 R.sup.5 represents straight-chain or branched alkyl having up to 10 carbon atoms, or and their pharmaceutically acceptable salts.