Preparation of benzyl ketones and an oxirane

US5146001A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Thomas Himmler · Odenthal, DE
• Udo Kraatz · Leverkusen, DE
• Wolfgang Kramer · Wuppertal, DE
• Klaus Stroech · Solingen, DE

Key dates

• Filing date: Jun 3, 1991
• Grant date: Sep 8, 1992
• Expiry date: Jun 3, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D305/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In the preparation of benzyl ketones of the formula ##STR1## a benzyl chloride of the formula ##STR2## is reacted with an acid chloride of the formula EQU R.sup.6 --CO--Cl (III) PA0 a) in a first stage with an excess of zinc powder in the presence of a diluent at a temperature between 80.degree. C. and 200.degree. C. under an inert gas atmosphere, and separating off the excess zinc powder, thereby to obtain a benzyl derivative of the formula ##STR3## and b) in a second stage reacting the benzyl derivative of the formual (IV) with an acid chloride of the formula (III) in the presence of a palladium catalyst and in the presence of a diluent at a temperature between 0.degree. C. and 150.degree. C. under an inert gas atmosphere.