Bis-arylphosphate ester antagonists of platelet activating factor

US5147864A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Allan Wissner · Monsey, US
• Kenneth E. Green · Houston, US
• Robert E. Schaub · Upper Saddle River, US

Key dates

• Filing date: Oct 18, 1990
• Grant date: Sep 15, 1992
• Expiry date: Oct 18, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6539
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention is novel compounds of the formula: ##STR1## wherein: X is a phenyl or naphthyl ring optionally substituted in any position with one to four substituents of; PA1 (i) --R.sub.2, wherein R.sub.2 is C.sub.1 -C.sub.25 alkyl, C.sub.1 -C.sub.25 alkenyl, C.sub.1 -C.sub.25 alkoxy, C.sub.1 -C.sub.25 thioalkyl, C.sub.1 -C.sub.25 alkenyloxy, phenyl, phenoxy, substituted phenyl or substituted phenoxy wherein the substituents are C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkoxy, halogen and trifluoremethyl; PA1 (ii) hydrogen, halogen, trifluoromethyl, cyano and nitro; PA1 (iii) --CO.sub.2 R.sub.3, --CONHR.sub.3, --CHO, OCONHR.sub.3, and --NHCOR.sub.3 wherein R.sub.3 is C.sub.1 -C.sub.25 alkyl, C.sub.1 -C.sub.25 alkenyl, phenyl or substituted phenyl wherein the substituents are C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkoxy, halogen or trifluoromethyl; PA0 R.sub.1 is one to four substituents on the aromatic ring which may be in any position and are hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy or halogen; PA0 --CH.sub.2 --Y is a single substituent of the aromatic ring which may occupy any position where Y is ##STR2## wherein R.sub.4 represents one to four substituent…