Affinity supports for hemoperfusion
US5149425A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 3, 1991 |
| Grant date | Sep 22, 1992 |
| Priority date | — |
| Expiry date | Apr 3, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8813
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of coating chromatographic particulate supports to provide a biocompatible outer layer of synthetic membrane-type film which prevents the release of fines but permits the adsorption of components to an affinity ligand is described. The matrix is provided with a membrane-type coating, which prevents leaching of fines, with a pore size of at least 20 angstroms. The coating is applied to a solid particulate under conditions where an integral membrane coat will be formed. It may also be necessary to control the size and number of pores of the membranes by treating a suspension of the solid support in a solvent which contains 0.1-1% of the support weight of a biocompatible polymer along with 0.5-5% of the weight of said polymer of a dissolved compatible pore-controlling component. The solvent is then removed from the suspension and the membrane-coated material used in extracorporeal treatment of body fluids or in other chromatographic techniques. The coating process can be conducted before or after the particulate support is functionalized and/or derivatized.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.