Polystyrenesulfonate-drug complex and solid dosage forms thereof

US5149523A · kind A · utility

Assignee

• Aktiebolaget Hassle · SE

Inventors

• Per Johan Lundberg · Mölndal, SE
• Karin Wingstrand · Mölndal, SE
• Kjell Andersson · Kungsbacka, SE
• Leif R. Simonsson · Göteborg, SE

Key dates

• Filing date: Dec 19, 1990
• Grant date: Sep 22, 1992
• Expiry date: Dec 19, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/585
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile , having the formula ##STR1## is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and technical properties of almokalant can be achieved when it is complexed as a salt with polystyrenesulfonic acid. Accordingly, the invention encompasses the almokalant salt and processes for the preparation of said salt. The invention further encompasses solid oral pharmaceutical dosage forms containing the almokalant-polystyrenesulfonate complex as well as methods for their manufacture as medicaments with action against cadiac arrhythmias.