Cytotoxic protein from Trichosanthes kirilowii
US5149528A · kind A · utility
3Cited by
4References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 13, 1989 |
| Grant date | Sep 22, 1992 |
| Priority date | — |
| Expiry date | Nov 13, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Purified cytotoxic proteins for use within therapeutic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline residues with equivalent positions at residue 43 and residue 46 in ricin A-chain. A method for preparing such a cytotoxic protein from the tissue of Trichosanthes kirilowii is also disclosed. The proteins may also be used within a method for inhibiting protein synthesis in selected cells.
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