Insulin derivatives, process for their preparation, their use and a pharmaceutical preparation containing them

US5149716A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Laszlo Vertesy · Eppstein, DE
• Karl Geisen · Frankfurt, DE
• Richard Bicker · Liederbach, DE

Key dates

• Filing date: Oct 26, 1990
• Grant date: Sep 22, 1992
• Expiry date: Oct 26, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to insulin derivatives of the formula III ##STR1## in which R.sup.30 and R.sup.31 together are OH, or R.sup.30 is a radical of a neutral, genetically encodable L-amino acid and R.sup.31 is OH or a physiologically acceptable organic group of basic character having up to 50 carbon atoms, whose synthesis involves 0 to 3 .alpha.-amino acids and whose optional terminal carboxyl function can be present free, as an ester function, as an amide function, as a lactone or reduced to CH.sub.2 OH, and R.sup.A-1 is a radical of a genetically encodable L-amino acid, and physiologically acceptable salts of said insulin derivative of the formula III.