Expression of the virally coded protease P2A of HRV2

US5149783A · kind A · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Wolfgang Sommergruber · Purkersdorf, AT
• Friederike Fessl · Mödling, AT
• Ernst Kuechler · Wien, AT
• Dieter Blaas · Wien, AT
• Timothy Skern · Wien, AT
• Manfred Zorn · Wien, AT
• Markus Duechler · Wien, AT
• Heinrich Kowalski · Wien, AT
• Peter-Hansen Volkmann · Wien, AT
• Ingrid Maurer-Fogy · Wien, AT
• Peter V. Pallai · Westwood, US

Key dates

• Filing date: Dec 23, 1988
• Grant date: Sep 22, 1992
• Expiry date: Dec 23, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/826
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention relates to a DNA molecule or a functional derivative thereof coding for a fusion protein, the fusion protein comprising an enzymatically active component and a non-enzymatically active polypeptide component which may be cleaved therefrom, an expression system which contains the DNA molecule, the use thereof as a test system for inhibitors of viral proteases, and an assay for identifying viral inhibitors.