Composition for use in organolithium synthesis reactions
US5149889A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 30, 1990 |
| Grant date | Sep 22, 1992 |
| Priority date | — |
| Expiry date | Oct 30, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F1/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is disclosed for the preparation of tertiary alcohols, alpha-alkyl substituted nitriles, alkyl-substituted imines or tertiary amines by alkylation of a starting material that is a carbonyl compound or a nitrile followed by hydrolysis wherein the alkylation is carried out with the aid of a reaction system formed by suspending a mixture of: PA1 substantially 15 to 25% by weight of methyllithium or ethyllithium; PA1 substantially 35 to 45% by weight of an inorganic compound selected from the group which consists of at least one metal oxide selected from the group which consists of SiO.sub.2, Al.sub.2 O.sub.3, and CaO, and synthetic anhydrous aluminum silicate; and PA1 substantially 35 to 45% by weight of a paraffin oil or wax; in an organic solvent selected from the group which consists of: PA1 C.sub.5 to C.sub.10 saturated aliphatic hydrocarbons, C.sub.5 to C.sub.10 cycloaliphatic hydrocarbons, aromatic hydrocarbons selected from the group which consists of benzene, toluene, and xylene, and aliphatic or cycloaliphatic ethers selected from the group which consists of diisopropyl ether, di-n-butyl ether, tert-butylether, tetrahydrofuran and dioxane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.