Derivatives of thioformamide

US5151436A · kind A · utility

Assignee

• Rhone-Poulenc Sante · FR

Inventors

• David C. Cook · London, GB
• Terance Hart · Chapel-en-le-Frith, GB
• Iain M. Mc Lay · Loughton, GB
• Malcolm Norman Palfreyman · Romford, GB
• Brian William Sharp · Romford, GB
• Roger J. A. Walsh · Romford, GB

Key dates

• Filing date: Aug 23, 1990
• Grant date: Sep 29, 1992
• Expiry date: Aug 23, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C.dbd.NOR.sup.1, >C.dbd.NN(R.sup.1).sub.2 or >C.dbd.NN(R.sup.1)CON(R.sup.1).sub.2 in which R.sup.1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R.sup.1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.