Patent · US Expired

Process for the production of 3-hydroxy-1,3,5(10)-estratrien-17-one

US5151533A · kind A · utility

0Cited by

0References

6Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Michael Buback · Bovenden, DE
Josef Hader · Berlin, DE
Hans-Peter Voegele · Göttingen, DE
ZaKarya Al-Massri · Göttingen, DE

Key dates

Filing date	Jul 22, 1991
Grant date	Sep 29, 1992
Priority date	—
Expiry date	Jul 22, 2011

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J1/0059
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the production of 3-hydroxy-1,3,5(10)-estratrien-17-one by pyrolysis of 1,4-androstadiene-3,17-dione in the presence of 1,2,3,4-tetrahydronaphthalene as hydrogen donor is described, by 1,2,3,4-tetrahydronaphthalene, preheated to a temperature of 450.degree.-850.degree. C., in a mixing zone being mixed with a solution, heated to a temperature of up to 300.degree. C., of 1,4-androstadiene-3,17-dione, in 1,2,3,4-tetrahydronaphthalene, the mixture being heated in a pyrolysis zone at a retention time of 0.001 to 60 seconds to temperatures of 450.degree.-700.degree. C. and the product leaving the pyrolysis zone being cooled off, which is characterized in that the pyrolysis is performed under a pressure of 3.5.times.10.sup.6 to 3.times.10.sup.8 Pa.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.