Method for purification of ibuprofen comprising mixtures
US5151551A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 6, 1990 |
| Grant date | Sep 29, 1992 |
| Priority date | — |
| Expiry date | Sep 6, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/43
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention pertains to a method of purifying ibuprofen-comprising reaction product mixtures. The method of purification is based on crystallization of ibuprofen from a hydrocarbon solvent and the discovery that there are impurity complexes in the ibuprofen-comprising reaction product mixtures which cannot be removed by crystallization from a hydrocarbon solvent. The method of the invention includes at least one step in which the impurity complex in a first ibuprofen-comprising mixture is destabilized or broken up, followed by crystallization of the ibuprofen from a second solution or mixture comprising the first ibuprofen-comprising mixture, whereby the impurities which were previously complexed can then be removed from the ibuprofen by the crystallization of ibuprofen from a solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.