Tripeptide derivatives and protease inhibitor composition comprising the same
US5153176A · kind A · utility
36Cited by
2References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 30, 1991 |
| Grant date | Oct 6, 1992 |
| Priority date | — |
| Expiry date | Jul 30, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tripeptide derivatives of formula (I) such as N-.epsilon.-(p-tosyl)-D-lysyl-L-prolyl-L-argininal have an activity of inhibiting a plurality of trypsin-like serine proteases, e.g., plasmin, thrombin, trypsin, kallikrein, factor Xa, urokinase, etc. in vivo. The tripeptide derivatives can be expected as novel protease inhibitors due to their remarkable pharmaceutical effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.