Conjugation of polymer to colony stimulating factor-1

US5153265A · kind A · utility

Assignee

• Cetus Corporation · US

Inventors

• Paula J. Shadle · Belmont, US
• Kirston E. Koths · Corona, US
• Margaret Moreland · Berkeley, US
• Nandini Katre · Corona, US
• Walter J. Laird · Pinole, US
• Lois Aldwin · San Mateo, US
• Danute E. Nitecki · Berkeley, US
• John D. Young · Taipei, TW

Key dates

• Filing date: Aug 30, 1990
• Grant date: Oct 6, 1992
• Expiry date: Aug 30, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.