S-sulfonated calcitonin derivatives
US5153308A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1989 |
| Grant date | Oct 6, 1992 |
| Priority date | — |
| Expiry date | Jun 7, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Calcitonin derivatives wherein at least one of the first cysteine residue and the seventh cysteine residue is S-sulfonated; processes for the production of the calcitonin derivatives comprising the steps of reacting a calcitonin with a sulfite anion or both a sulfite anion and an oxidizing agent to form the S-sulfonated derivative, and recovering the sulfonated calcitonin derivative; a pharmaceutical composition comprising the S-sulfonated calcitonin derivative; and a method of treating a patient having a disease wherein a decrease of a serum calcium level is desired, by administering the S-sulfonated calcitonin derivative to the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.