7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease

US5153327A · kind A · utility

Assignee

• E.R. SQUIBB & SONS. INC. · US

Inventors

• Raj N. Misra · Hopewell, US
• Philip M. Sher · Plainsboro, US
• Philip D. Stein · Pennington, US
• Steven E. Hall · Ewing Township, US
• David Floyd · Pennington, US
• Joel C. Barrish · Richboro, US

Key dates

• Filing date: Oct 10, 1991
• Grant date: Oct 6, 1992
• Expiry date: Oct 10, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C45/29
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula ##STR1## wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH.sub.2).sub.2 --, --CH.dbd.CH-- or ##STR2## wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is ##STR3## then Y cannot be O, and when Z is --CH.dbd.CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=; R is CO.sub.2 H, CO.sub.2 lower alkyl, CH.sub.2 OH, CO.sub.2 alkali metal, CONHSOR.sup.3 m CONHR.sup.3a or --CH.sub.2 -5-tetrazolyl, X is O, S or NH; and where R.sup.1, R.sup.2, R.sup.3 and R.sup.3a are as defined herein.