Radioiodinated benzamines method of their use as radioimaging agents
US5154913A · kind A · utility
9Cited by
5References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 28, 1991 |
| Grant date | Oct 13, 1992 |
| Priority date | — |
| Expiry date | May 28, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/09
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.